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Updated: Dec 14, 2025

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
A student practical to conceptualize the importance of Poiseuille's law and flow control in the cardiovascular system
Andrew P Holmes1, Clare J Ray1, Prem Kumar1
1Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
Abstract:
The laboratory practical reported here is based in Poiseuille's law and utilizes low-cost laboratory consumable items, thereby making it easy to deploy in any teaching laboratory. In the practical, students take an experimental approach of individually changing physical variables and measuring fluid flow rates. Plotting these results allows them to discuss the effect each variable has on flow. Furthermore, students enhance their appreciation of experimental errors and variability by making repeat measurements. In the follow-up teaching session, the students are encouraged to apply their experimental findings to the cardiovascular system and the control of blood flow both at rest and under conditions of altered cardiac output, such as during exercise. By tackling the topic of flow control as a core concept, it allows the students to then apply their understanding in wider physiological contexts, such as airflow in the respiratory system.
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