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Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer

Hyocheol Bae1, Jin-Young Lee2, Jisoo Song3

  • 1Department of Biotechnology, Korea University, Seoul, Republic of Korea.

Journal of Cellular Physiology
|July 23, 2020
PubMed

Insights

Osthole, a natural compound, shows promise in fighting ovarian cancer by targeting key cell pathways. This research highlights its potential as a new therapeutic agent for ovarian cancer treatment.

Area of Science:

  • Pharmacology
  • Oncology
  • Natural Products Chemistry

Background:

  • Osthole is a natural coumarin with diverse reported biological activities.
  • Ovarian cancer remains a significant health challenge requiring novel therapeutic strategies.

Purpose of the Study:

  • To investigate osthole as a potential anticancer agent against ovarian cancer.
  • To elucidate the mechanisms underlying osthole's anticancer effects in ovarian cancer cells.

Main Methods:

  • In vitro studies on ES2 and OV90 ovarian cancer cell lines.
  • Investigation of the endoplasmic reticulum-mitochondrial axis and calcium-dependent pathways.
  • Analysis of the phosphatidylinositol 3-kinase/mitogen-activated protein kinase signaling pathway.
  • In vivo evaluation using a zebrafish xenograft tumor-formation model.

Main Results:

  • Osthole demonstrated significant suppression of ovarian cancer cell progression.
  • The endoplasmic reticulum-mitochondrial axis and calcium signaling were identified as key mediators of osthole's action.
  • Osthole's mechanism involves targeting the phosphatidylinositol 3-kinase/mitogen-activated protein kinase pathway.
  • Effective anti-tumor activity was observed in a three-dimensional zebrafish model, simulating an anchorage-independent microenvironment.

Conclusions:

  • Osthole exhibits potent anticancer properties against ovarian cancer.
  • The study reveals novel endoplasmic reticulum-mitochondrial axis-mediated and calcium-dependent mechanisms of osthole.
  • Osthole shows significant therapeutic potential for ovarian cancer, warranting further clinical investigation.
Keywords:
apoptosiscalcium homeostasisostholeovarian cancerzebrafish

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