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Current knowledge on autoantigens and autoantibodies in psoriasis
Lisa Lynn Ten Bergen1,2, Aleksandra Petrovic1, Anders Krogh Aarebrot1
1Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Scandinavian Journal of Immunology
|July 23, 2020
Summary
Psoriasis is an immune-mediated skin disease. Recent discoveries identify specific autoantigens and autoantibodies, offering new insights into psoriasis and psoriatic arthritis pathogenesis and potential targeted therapies.
Area of Science:
- Immunodermatology
- Autoimmunity
- Molecular mechanisms of skin inflammation
Background:
- Psoriasis is a genetically influenced, immune-mediated inflammatory skin condition.
- Autoimmune pathomechanisms are evident, but specific targets remained elusive until 2014.
- Four key psoriasis autoantigens have since been identified.
Purpose of the Study:
- To review current research on psoriasis autoantigens and associated autoantibodies.
- To explore their role in the pathogenesis of psoriatic plaques and psoriatic arthritis.
- To discuss the potential for antigen-targeted therapeutic strategies.
Main Methods:
- Review of clinical and experimental evidence.
- Identification and characterization of psoriasis autoantigens (LL-37, ADAMTSL5, PLA2G4D, keratin 17).
- Analysis of autoreactive T cells and autoantibodies in patients.
Main Results:
- Four specific autoantigens implicated in psoriasis pathogenesis.
- Autoreactive T cells found in patients with moderate-to-severe plaque psoriasis.
- Autoantibodies against LL-37 and ADAMTSL5 associated with psoriatic arthritis.
Conclusions:
- Psoriasis exhibits clear autoimmune characteristics.
- Identified autoantigens and autoantibodies are crucial in disease development.
- Antigen-targeted therapies represent a promising future treatment avenue for psoriasis and PsA.
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