Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report.

Bipolar disorders·2026

Same author

Brainwide Structural Markers of Familial and Clinical Risk for Bipolar Disorder in Youth.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026

Same author

Validation and Extension of a Risk Calculator to Predict Mood Recurrence in Young People with Bipolar Disorder.

medRxiv : the preprint server for health sciences·2026

Same author

Agreement between smartphone-based mobile sensing and actigraphy sleep metrics in young people with bipolar disorder.

medRxiv : the preprint server for health sciences·2026

Same author

Effective connectivity of implicit emotion processing in adolescent psychiatric inpatients: Dynamic causal modeling across bipolar disorder and other psychopathologies.

Journal of affective disorders·2026

Same author

A Critical Overview of the Validity of the Current Concept of Bipolar Disorder.

Journal of personalized medicine·2025

Search research articles

Related Experiment Video

Updated: Dec 14, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Mindfulness-based intervention to decrease mood lability in at-risk youth: Preliminary evidence for changes in

Danella M Hafeman¹, A Noelle Ostroff², Jamie Feldman³

¹Department of Psychiatry, University of Pittsburgh School of Medicine, United States; University of Pittsburgh Medical Center, United States.

Journal of Affective Disorders

|July 23, 2020

Summary

This summary is machine-generated.

Mindfulness training improved brain connectivity and reduced moodiness in at-risk youth. Increased resting-state functional connectivity (rsFC) between the posterior cingulate cortex (PCC) and dorsolateral prefrontal cortex (DLPFC) was linked to better emotion regulation.

Keywords:

Bipolar disorder Emotion regulation Mindfulness Mood lability Neuroimaging Resting-state functional connectivity

More Related Videos

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

Published on: July 1, 2015

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Related Experiment Videos

Last Updated: Dec 14, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

Published on: July 1, 2015

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Area of Science:

Neuroscience
Psychiatry
Developmental Psychology

Background:

Youth at familial risk for bipolar disorder (BD) often exhibit mood lability, a precursor to BD onset.
Mindfulness-based interventions (MBI) may enhance emotion regulation by increasing resting-state functional connectivity (rsFC) between the posterior cingulate cortex (PCC) and executive control network (ECN).

Purpose of the Study:

To investigate the effects of an MBI on PCC-ECN rsFC and mood lability in at-risk youth.
To explore the relationship between changes in rsFC and mood-related outcomes.

Main Methods:

Recruited 35 at-risk youth (10-14 years) with a family history of BD and mood lability, plus 21 healthy controls.
At-risk youth underwent an 8-week MBI, with brain scans pre/post intervention and a 3-month follow-up.
Assessed changes in PCC-ECN rsFC and its correlation with mood lability and emotion suppression.

Main Results:

Following MBI, at-risk youth showed increased PCC-DLPFC rsFC, unlike controls.
At-risk youth reported significant improvements in mindfulness, reduced mood lability, and less negative emotion suppression post-MBI.
Greater PCC-DLPFC rsFC increases predicted reduced mood lability and emotion suppression at follow-up.

Conclusions:

PCC-DLPFC rsFC represents a potential neural target for MBI in at-risk youth.
MBI may improve mood lability through enhanced PCC-DLPFC connectivity.