Related Experiment Video

Updated: Dec 14, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.9K

The biological and diagnostic roles of MicroRNAs in meningiomas

Lei Wang1, Shengpan Chen2,3, Yan Liu4

  • 1Department of Neurosurgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Reviews in the Neurosciences
|July 23, 2020
PubMed

Insights

MicroRNAs (miRNAs) are small RNAs regulating genes. This review explores their role in meningioma, highlighting their potential as diagnostic biomarkers and therapeutic targets for this brain tumor.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNAs are implicated in tumorigenesis and cancer progression.
  • The specific roles and mechanisms of miRNA dysregulation in meningioma pathogenesis remain unclear.

Purpose of the Study:

  • To review aberrant miRNA expression in meningioma identified by high-throughput microarray profiling.
  • To explore the potential of miRNAs as biomarkers and therapeutic targets for meningioma.
  • To summarize mechanisms of miRNA-mediated meningioma occurrence and progression.

Main Methods:

  • Literature review of existing research on meningioma and miRNA.
  • Analysis of high-throughput microarray data for aberrantly expressed miRNAs in meningioma.
  • Synthesis of recent studies on miRNA-mediated mechanisms in meningioma.

Main Results:

  • Identified several aberrantly expressed miRNAs in meningioma through microarray profiling.
  • Highlighted the potential of specific miRNAs as diagnostic biomarkers.
  • Indicated the therapeutic potential of targeting miRNAs in meningioma treatment.

Conclusions:

  • miRNA deregulation is a significant factor in meningioma development and progression.
  • miRNAs hold promise as novel biomarkers for meningioma diagnosis.
  • Targeting miRNAs could offer new therapeutic strategies for meningioma.
Keywords:
biological rolesbiomarkerdiagnosismeningiomamicroRNAs

More Related Videos

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

231
Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

19.8K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.5K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.7K