Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

727
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
727
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

675
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
675
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

787
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
787
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

542
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
542
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.0K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.0K
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

338
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
338

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Common γ-chain cytokines induce an epigenomically plastic precursor-like KIT<sup>+</sup> ILC2 state linked to immune disease susceptibility.

The Journal of allergy and clinical immunology·2026
Same author

HLA-DRB1*01:03 in patients with inflammatory bowel disease: a genotype-phenotype association study.

The lancet. Gastroenterology & hepatology·2026
Same author

Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis.

Nature genetics·2026
Same author

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease.

The New England journal of medicine·2026
Same author

Spatial transcriptomics reveals clonal relationships between intraductal carcinoma and adjacent invasive prostate cancer.

Histopathology·2026
Same author

Cell-type-resolved genetic variation shapes inflammatory bowel disease risk.

Nature·2026

Related Experiment Video

Updated: Dec 14, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.4K

Somatic Evolution in Non-neoplastic IBD-Affected Colon.

Sigurgeir Olafsson1, Rebecca E McIntyre1, Tim Coorens1

  • 1Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.

Cell
|July 23, 2020
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD) accelerates colon cell mutation rates by 2.4-fold, driving widespread clonal expansions. Somatic mutations in key genes suggest a causal role in IBD pathogenesis.

Keywords:
Crohn's diseaseIL17PIGRZC3H12Ainflammatory bowel diseaseintestinal epitheliamutation ratemutational signaturessomatic mutationsulcerative colitis

More Related Videos

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.4K
In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

35.7K

Related Experiment Videos

Last Updated: Dec 14, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.4K
Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.4K
In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

35.7K

Area of Science:

  • Genomics
  • Gastroenterology
  • Cancer Biology

Background:

  • Inflammatory bowel disease (IBD) is a chronic condition linked to increased gastrointestinal cancer risk.
  • Understanding the genomic landscape of IBD is crucial for elucidating disease mechanisms and cancer development.

Purpose of the Study:

  • To investigate somatic mutation patterns in colonic epithelial cells of IBD patients.
  • To compare the mutation landscape of IBD-affected colons with that of healthy colons.
  • To identify genes and pathways under positive selection in IBD.

Main Methods:

  • Whole-genome sequencing of 446 colonic crypts from 46 IBD patients.
  • Comparison with 412 colonic crypts from 41 non-IBD controls.
  • Analysis of mutation rates, clonal expansions, and selection pressures.

Main Results:

  • IBD colonic epithelial cells exhibit a 2.4-fold higher average mutation rate than healthy controls.
  • Accelerated mutational processes, common in normal colons, drive this increase.
  • Widespread, millimeter-scale clonal expansions were observed in IBD, unlike in the normal colon.
  • Positive selection identified non-synonymous mutations in ARID1A, FBXW7, PIGR, ZC3H12A, and IL-17/TLR pathway genes.

Conclusions:

  • Distinct selection mechanisms operate in the colitis-affected colon compared to the normal colon.
  • Somatic mutations may play a causal role in the pathogenesis of inflammatory bowel disease.
  • These findings provide insights into IBD-associated cancer development.