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Culturing and Manipulation of O9-1 Neural Crest Cells
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Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis

Marina Peralta1, Laia Ortiz Lopez1, Katerina Jerabkova1

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France.

Cell Reports
|July 23, 2020
PubMed
Summary

Intraflagellar transport (IFT) proteins regulate heart development by modulating YAP1, a key component of the Hippo pathway. This discovery reveals a novel mechanism linking cilia function to congenital heart disease pathogenesis.

Keywords:
BMPHippoIntraflagellar transport (IFT)Yap1cargiogenesisprimary ciliaproepicardium

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