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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Dec 14, 2025

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

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COVID-19 and hydatidiform mole.

Ahmed M Abbas1,2, Lobna Ahmed2,3, Amera S Salem2,3

  • 1Department of Obstetrics & Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|July 23, 2020
PubMed
Summary

The study explores how COVID-19 may increase the risk of hydatidiform mole (HM) in pregnant individuals. It reviews the roles of NLRP7, cytokines, zinc, and leukocytes in HM development during the pandemic.

Keywords:
COVID-19Gestational trophoblastic diseasesHydatidiform molecoronavirus

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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

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Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic has caused global health challenges, impacting pregnant individuals.
  • Pregnant patients with COVID-19 exhibit immune dysregulation, potentially leading to adverse pregnancy outcomes.
  • Abnormal outcomes include hydatidiform mole (HM), recurrent pregnancy loss, and early-onset preeclampsia.

Purpose of the Study:

  • To summarize the potential association between COVID-19 and the development of hydatidiform mole (HM).
  • To review the role of key biological factors in the pathogenesis of HM in the context of COVID-19.

Main Methods:

  • Literature review focusing on the interplay between COVID-19 infection and HM development.
  • Analysis of the roles of NOD-Like Receptor (NLR) Family Pyrin Domain Containing 7 (NLRP7), cytokines, zinc, and leukocytes.

Main Results:

  • COVID-19-induced immune dysregulation may contribute to HM pathogenesis.
  • NLRP7, cytokines, zinc, and leukocytes are implicated in the biological mechanisms linking COVID-19 and HM.

Conclusions:

  • COVID-19 may be associated with an increased risk of hydatidiform mole.
  • Further research is needed to elucidate the precise mechanisms involving NLRP7, cytokines, zinc, and leukocytes in COVID-19-related HM.