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Updated: Dec 14, 2025

Preparation, Purification, and Use of Fatty Acid-containing Liposomes
Published on: February 9, 2018
Oral delivery of natural compounds by phospholipid vesicles
Maria Manconi1, Carla Caddeo1, Maria Letizia Manca1
1Department of Life & Environmental Sciences, University of Cagliari, Via Ospedale 72, Cagliari, 09124, Italy.
Abstract:
The purpose of this report is to summarize and critically analyze emerging trends in phospholipid vesicles for the oral delivery of natural compounds. Liposomes have long been used as delivery systems, thanks to their ability to incorporate diverse bioactives, their biocompatibility and safety. However, the efficacy of oral liposomes is hampered by their low stability under the harsh conditions of the gastrointestinal tract. Different approaches have been utilized with the aim of improving the stability of liposomes and the payload after oral administration. This report provides an overview on the phospholipid vesicles used for oral delivery of natural compounds, exploring the current strategies to improve their performance by modifying the lipid bilayer composition and assembly or the physical state.
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