Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Semaglutide and Neovascular Age-Related Macular Degeneration Among Adults with Type 2 Diabetes: An OHDSI Network Study.

Ophthalmology·2026

Same author

The internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells in vivo.

Science translational medicine·2026

Same author

PyOPV: An Open-Source Python Package for Ophthalmic Visual Field Data Management.

Journal of glaucoma·2026

Same author

Assessing the Accuracy of Artificial Intelligence-Generated Clinical Summaries From Ambulatory Glaucoma Subspecialty Clinical Encounters.

Translational vision science & technology·2026

Same author

Dual-Level Pattern Tree for Visual Field Improves Glaucoma Progression and Polygenic Risk Prediction.

Translational vision science & technology·2025

Same author

The Impact of Myopia on Regional Visual Field Loss and Progression in Glaucoma.

Translational vision science & technology·2025

Search research articles

Related Experiment Video

Updated: Dec 14, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Defining glaucomatous optic neuropathy using objective criteria from structural and functional testing.

Jayant Venkatramani Iyer¹, Michael V Boland², Joan Jefferys²

¹Glaucoma, Singapore National Eye Centre, Singapore, Singapore.

The British Journal of Ophthalmology

|July 24, 2020

Summary

Objective criteria using optical coherence tomography (OCT) and perimetry can define glaucomatous optic neuropathy (GON). This aids consistent comparisons in glaucoma research studies.

Keywords:

Diagnostic tests/Investigation Epidemiology Field of vision Glaucoma Imaging Optic Nerve

More Related Videos

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

Related Experiment Videos

Last Updated: Dec 14, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

Area of Science:

Ophthalmology
Medical Imaging
Neurology

Background:

Glaucomatous optic neuropathy (GON) diagnosis relies on subjective clinical assessment.
Standardized objective criteria are needed for consistent comparisons in glaucoma research.

Purpose of the Study:

To establish objective criteria for defining GON using optical coherence tomography (OCT) and perimetry.
To facilitate comparisons across glaucoma research studies.

Main Methods:

Cross-sectional study of 2580 eyes from 1531 adult glaucoma patients across nine global centers.
Evaluated physician diagnosis, OCT, and perimetry data against a global consensus panel of 176 glaucoma specialists.
Compared objective measures from OCT and perimetry to physician-graded diagnostic levels (definite, probable, not GON).

Main Results:

Neither OCT nor perimetry alone achieved adequate specificity (<90%) for defining GON.
The optimal definition combined abnormal OCT nerve fiber layer quadrants with a matching abnormal Glaucoma Hemifield Test.
This combined approach yielded 77% sensitivity at 98% specificity.

Conclusions:

Objective criteria for defining GON are practical and valuable.
These criteria can supplement subjective clinical assessments in glaucoma research.
Standardized definitions improve the comparability of glaucoma research studies.