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Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
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Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

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Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
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Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

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The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
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Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

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The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
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Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

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The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
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Renal Clearance01:23

Renal Clearance

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The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
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Related Experiment Video

Updated: Dec 14, 2025

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70
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Glomerular Hyperfiltration and Cancer: A Nationwide Population-Based Study.

Yaerim Kim1,2, Soojin Lee3, Yeonhee Lee3

  • 1Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|July 24, 2020
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Glomerular hyperfiltration, a sign of high kidney filtration, is linked to increased cancer risk in Asian populations. This finding highlights the need for vigilance regarding potential hidden malignancies.

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Area of Science:

  • Nephrology
  • Oncology
  • Epidemiology

Background:

  • Glomerular hyperfiltration is a known risk factor for all-cause mortality.
  • The association between glomerular hyperfiltration and cancer development requires further investigation, especially in diverse populations.

Purpose of the Study:

  • To investigate the link between glomerular hyperfiltration and the incidence of various cancers in an Asian population.
  • To assess the predictive value of glomerular hyperfiltration for cancer development.

Main Methods:

  • Retrospective analysis of the Korean National Health Insurance Service database (2012-2013).
  • Glomerular hyperfiltration defined as the 95th percentile or greater, stratified by sex and age.
  • Multivariate Cox regression analysis to evaluate the association between hyperfiltration and cancer development.

Main Results:

  • A total of 1,953,123 health screenings were analyzed with a median follow-up of 4.4 years.
  • Glomerular hyperfiltration showed a significant association with digestive organ cancers.
  • Increased risks observed for stomach (aHR=1.22), colorectal (aHR=1.16), and liver/intrahepatic malignancies (aHR=1.35).

Conclusions:

  • Glomerular hyperfiltration is associated with an elevated risk of developing specific cancers, including stomach, colorectal, and liver cancers.
  • Glomerular hyperfiltration should be recognized as a potential indicator for underlying malignancies and warrants further medical evaluation.