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Related Concept Videos

Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

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The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
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Drug Classes and Categories01:25

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Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Therapeutic Drug Monitoring: Overview and Classification01:16

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Do DSM classifications help or hinder
drug development?
.

Michael Davidson1, Cristian Gabos-Grecu2

  • 1Professor and Chair, University of Nicosia Medical School, Nicosia, Cyprus.

Dialogues in Clinical Neuroscience
|July 24, 2020
PubMed
Summary
This summary is machine-generated.

Psychotropic drug development currently relies on Diagnostic and Statistical Manual of Mental Disorders (DSM) syndromes. While criticized for heterogeneity, exploring transdiagnostic approaches beyond DSM is recommended, though no superior alternative exists for communication.

Keywords:
classificationdrug developmentpsychotropic

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Area of Science:

  • Psychopharmacology
  • Neuroscience
  • Clinical Psychology

Background:

  • Current psychotropic drug development targets Diagnostic and Statistical Manual of Mental Disorders (DSM) syndromes.
  • This facilitates communication between drug developers, regulators, and prescribers for targeted treatment.
  • Criticism exists due to biological heterogeneity of DSM syndromes and nonspecific psychotropic effects.

Purpose of the Study:

  • To review the advantages and disadvantages of the current DSM-based psychotropic drug development practice.
  • To explore potential alternative approaches to psychotropic drug development.
  • To assess the feasibility of transdiagnostic development strategies.

Main Methods:

  • Literature review of current practices in psychotropic drug development.
  • Analysis of criticisms regarding DSM-based targeting.
  • Evaluation of alternative diagnostic systems and transdiagnostic approaches.

Main Results:

  • The current DSM-based system aids communication but faces challenges due to syndrome heterogeneity.
  • Psychotropic effects are often nonspecific, limiting precise matching with DSM diagnoses.
  • Transdiagnostic development, free from DSM boundaries, is suggested as a future direction.

Conclusions:

  • Efforts should explore psychotropic development transdiagnostically, moving beyond current DSM limitations.
  • No alternative diagnostic system currently surpasses the DSM for stakeholder communication in drug development.
  • Balancing innovation with established communication frameworks is crucial for future psychotropic research.