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LncRNA & Wnt signaling in colorectal cancer

Zeeshan Javed1, Khushbukhat Khan2, Haleema Sadia3

  • 1Office for Research Innovation and Commercialization, Lahore Garrison University, Sector-C, Phase VI, DHA, Lahore, Pakistan.

Cancer Cell International
|July 24, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators in colorectal cancer (CRC) that target the Wnt signaling pathway. This review highlights their role in CRC pathogenesis and potential as therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Wnt signaling pathway dysregulation is central to colorectal cancer (CRC) development.
  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators of gene expression in cancer.
  • The specific roles of lncRNAs in Wnt-mediated CRC pathogenesis remain underexplored.

Purpose of the Study:

  • To review the significance of lncRNAs in colorectal cancer pathogenesis.
  • To explore the therapeutic potential of targeting Wnt signaling via lncRNAs in CRC.
  • To elucidate the role of lncRNAs in regulating apoptosis and proliferation in CRC.

Main Methods:

  • Literature review of studies on lncRNAs, Wnt signaling, and colorectal cancer.
  • Analysis of the regulatory mechanisms of lncRNAs at transcriptional and translational levels.
  • Synthesis of current knowledge on lncRNA involvement in CRC cell processes.

Main Results:

  • lncRNAs play a vital role in regulating cellular processes relevant to CRC.
  • Targeting the Wnt pathway using lncRNAs presents a promising therapeutic strategy for CRC.
  • Further research is needed to fully understand lncRNA functions in CRC apoptosis and proliferation.

Conclusions:

  • lncRNAs are crucial in Wnt-mediated colorectal cancer.
  • Targeting lncRNAs offers a novel therapeutic avenue for CRC treatment.
  • Understanding lncRNA-Wnt interactions is pivotal for future CRC therapies.
Keywords:
Colorectal cancerTherapeutics strategyWnt signalinglncRNA

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