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Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia
Zachary A Miller1, Salvatore Spina1, Mikhail Pakvasa1
1Department of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA.
Brain Communications
|July 24, 2020
Summary
Developmental dyslexia may increase susceptibility to Alzheimer's disease, particularly logopenic variant primary progressive aphasia. Neuropathological findings reveal overlapping neurodevelopmental and Alzheimer's changes in affected brain regions.
Area of Science:
- Neuroscience
- Neuropathology
- Genetics
Background:
- Increased prevalence of dyslexia observed in primary progressive aphasia, especially logopenic variant.
- Logopenic variant primary progressive aphasia is commonly associated with Alzheimer's disease pathology.
Purpose of the Study:
- To describe neuropathological findings in three patients with logopenic variant primary progressive aphasia and developmental dyslexia.
- To investigate the relationship between early neurodevelopmental changes and later neurodegenerative disease susceptibility.
Main Methods:
- Clinical case report series.
- Neuropathological examination of brain tissue.
- Analysis of Alzheimer's disease and neurodevelopmental pathology.
Main Results:
- All three patients showed cerebrocortical microdysgenesis alongside Alzheimer's disease pathology.
- Pathological changes overlapped in perisylvian brain regions, affecting phonological processing.
- Findings suggest a link between early-life neurodevelopment and late-onset Alzheimer's disease.
Conclusions:
- Early-life neurodevelopmental alterations may influence susceptibility to neurodegenerative diseases like Alzheimer's.
- This interplay could contribute to non-amnestic, early-onset Alzheimer's presentations.
- Further research on lifespan neurobiological vulnerability is warranted.
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