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Updated: Dec 14, 2025
Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
Published on: May 8, 2017
A matrix metalloproteinase activation probe for painting human tumours
Bethany Mills1, Dominic Norberg, Kevin Dhaliwal
1Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, 147 Little France Crescent, EH16 4TJ Edinburgh, UK.
Abstract:
A probe that allows specific 'painting' of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that "fluorescently paints" human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.
