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Endocrine Therapy for Breast Cancer: A Model of Hormonal Manipulation

Simon J Johnston1, Kwok-Leung Cheung2

  • 1School of Medicine, University of Nottingham, Nottingham, UK.

Oncology and Therapy
|July 24, 2020
PubMed

Insights

Hormonal manipulation targeting oestrogen receptor (ER) is key in treating most breast cancers. This review outlines endocrine therapy principles and evidence to guide optimal clinical strategies.

Area of Science:

  • Oncology
  • Endocrinology
  • Genetics

Background:

  • Oestrogen receptor (ER) drives 70% of breast cancers.
  • Endocrine therapies targeting ER are highly effective anticancer strategies.
  • Novel targeted agents are increasingly combined with endocrine therapies.

Purpose of the Study:

  • To outline principles of hormonal manipulation in breast cancer.
  • To review key evidence underpinning current endocrine therapy clinical practice.
  • To guide optimal strategy selection in evolving treatment landscapes.

Main Methods:

  • Review of established endocrine therapy principles.
  • Analysis of clinical evidence for current breast cancer treatment.
  • Discussion of combination therapy benefits and risks.

Main Results:

  • Endocrine therapies targeting ER are a cornerstone of breast cancer treatment.
  • Combination therapies offer potential for maximized efficacy.
  • Balancing efficacy gains against increased side effect risks is crucial.

Conclusions:

  • Understanding hormonal manipulation is vital for breast cancer management.
  • Interpreting clinical data is essential for selecting optimal endocrine therapy strategies.
  • The role of endocrine therapy in breast cancer continues to expand, requiring careful consideration of treatment options.
Keywords:
Breast cancerCombination therapyEndocrine therapyHormoneOestrogen receptorTargeted therapy

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