Gyral-sulcal contrast in intrinsic functional brain networks across task performances

Functional mechanism of the brain and its relationship with the brain structural substrate have been an interest for multiple disciplines for centuries. Recently, gyri and sulci, two basic cortical folding patterns, have been demonstrated to act different functional roles. Specifically, a variety of functional MRI (fMRI) studies have consistently suggested that gyri represent a global functional center while sulci serve as a local functional unit under either resting state or task stimulus, which are further supported by brain structural analysis reporting that gyri have thicker cortex and denser long-distance axonal fibers. However, the consistency of such gyral-sulcal functional difference across different task stimuli, as well as its association with task conditions, remains to be explored. To this end, we used intrinsic networks as the testbed for cross-task comparison, and adopted a computational framework of dictionary learning and sparse representation of whole-brain fMRI signals to systematically examine the potential gyral-sulcal difference in signal representation residual (SRR) which reflected the degree of global functional communication. Using all seven task-based fMRI datasets in Human Connectome Project Q1 release, we found that within the intrinsic functional networks, the fMRI SRR was significantly smaller on gyral regions than on sulcal regions across different task stimuli, indicating that gyral regions were more involved in global functions of the brain and interregional communications. Moreover, the magnitudes of such gyral-sulcal difference varied across task conditions and intrinsic networks. Our work adds novel explanation and insight to the existing knowledge of functional differences between gyri and sulci.