Direct electrochemical reductive amination between aldehydes and amines with a H/D-donor solvent
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Updated: Dec 14, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Huanliang Hong1, Zirong Zou1, Gen Liang1
1School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China. wyuchemhyb@126.com leeyib268@126.com.
Abstract:
A novel electrochemical synthesis protocol has been achieved for reductive amination between aldehydes and amines in undivided cells at room temperature. Under metal-free and external-reductant-free electrolysis conditions, various important secondary amine products are obtained in moderate-to-high yields. Deuterium-labeling experiments have demonstrated that low-toxicity DMSO acts both as a solvent and a H-donor in the reaction. On this basis, various deuterium-labeled products with good-to-excellent D-incorporation have been synthesized by using DMSO-d6 as a solvent. Furthermore, a molecule with GR-antagonistic activity has been synthesized through further sulfonylation.
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