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Updated: Sep 15, 2026
A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
Published on: November 15, 2019
Transient Macular Thinning during the Use of Heavy Silicone Oil, Densiron 68
Avner Hostovsky1,2, Mark S Mandelcorn1,2, Efrem D Mandelcorn1,2
1Department of Ophthalmology and Vision Sciences, University of Toronto , Toronto, Canada.
Background:
To evaluate the effect of short-term Densiron tamponade on macular thickness.
Methods:
Retrospective case series. Data were collected from charts of patients who received short-term (less than 90 days) Densiron tamponade. The OCT parameters were compared between Densiron in situ and after Densiron removal and to the fellow eye.
Results:
Twenty eyes were included in the analysis. Although there was a trend toward thinner CRT with Densiron in situ in situ the operated eye when compared to the fellow eye (248 and 264 microns, respectively, p = .066), this difference disappeared after DR. At the final OCT there was a statistically significant recovery in the CRT (from 248 to 277 microns, P = .001) and no statistical difference between operated and the fellow eye (p = .265) with no evidence of ERM or CME.
Conclusions:
We found transient macular thinning that resolved after Densiron removal with no evidence of long-term macular thinning in eyes treated with Densiron tamponade for retinal detachment.
