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Updated: Dec 14, 2025

Measuring the 50% Haemolytic Complement CH50 Activity of Serum
Published on: March 29, 2010
The interaction between the complement system and hemostatic factors
Selin Oncul1, Vahid Afshar-Kharghan2
1Department of Biochemistry, Faculty of Pharmacy, The University of Hacettepe, Ankara, Turkey.
Purpose Of Review:
To discuss the crosstalk between the complement system and hemostatic factors (coagulation cascade, platelet, endothelium, and Von Willebrand Factor), and the consequences of this interaction under physiologic and pathologic conditions.
Recent Findings:
The complement and coagulation systems are comprised of serine proteases and are genetically related. In addition to the common ancestral genes, the complement system and hemostasis interact directly, through protein-protein interactions, and indirectly, on the surface of platelets and endothelial cells. The close interaction between the complement system and hemostatic factors is manifested both in physiologic and pathologic conditions, such as in the inflammatory response to thrombosis, thrombosis at the inflamed area, and thrombotic complications of complement disorders.
Summary:
The interaction between the complement system and hemostasis is vital for homeostasis and the protective response of the host to tissue injury, but also results in the pathogenesis of several thrombotic and inflammatory disorders.
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