PET Imaging of a Unique Case of Multiple Myeloma in an Adolescent
Larry A Binkovitz1, Samuel L Sutton2, Martha Q Lacy3
1From the Department of Radiology, Mayo Clinic, Rochester, MN.
Abstract:
Pediatric solitary plasmacytomas are extremely rare, with only 14 cases previously reported. None of these reports included PET imaging findings. We present PET/CT and PET/MRI imaging findings in a 15-year-old boy with what was initially thought to be a solitary plasmacytoma, which later developed into multiple myeloma. The initial PET/CT of solitary plasmacytoma, as well as postradiotherapy PET/MRI findings with the new lesions suggestive of multiple myeloma, are presented.
Insights
Pediatric solitary plasmacytoma is rare, with this case detailing novel PET/CT and PET/MRI imaging. This imaging revealed progression from solitary plasmacytoma to multiple myeloma in a young patient.
Area of Science:
- Oncology
- Radiology
- Pediatric Hematology/Oncology
Background:
- Solitary plasmacytomas in pediatric patients are exceptionally rare, with limited prior case reports.
- Existing literature lacks detailed information on the use of Positron Emission Tomography (PET) imaging in these cases.
Observation:
- This report details the case of a 15-year-old male initially diagnosed with solitary plasmacytoma.
- The patient underwent both PET/CT and PET/MRI imaging for diagnostic and follow-up assessment.
Findings:
- Initial PET/CT imaging characterized the solitary plasmacytoma.
- Subsequent PET/MRI imaging after radiotherapy revealed new lesions, indicating a transformation to multiple myeloma.
Implications:
- This case highlights the utility of advanced PET imaging modalities (PET/CT and PET/MRI) in diagnosing and monitoring rare pediatric plasma cell neoplasms.
- The findings underscore the potential for solitary plasmacytoma to evolve into multiple myeloma, even in adolescents, emphasizing the need for vigilant follow-up.
- This presentation provides valuable insights into the imaging characteristics of pediatric solitary plasmacytoma and its progression, contributing to the understanding of rare hematologic malignancies.
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