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Published on: December 19, 2020
The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
Kenneth Mangion1,2, Andrew Morrow1,2, Catherine Bagot3
1British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Insights
This study investigates cardiovascular and multisystem effects of COVID-19 in hospitalized patients. It aims to determine the prevalence of myocardial inflammation and other organ involvement post-discharge.
Area of Science:
- Cardiology
- Infectious Diseases
- Multisystemic Illness
Background:
- COVID-19 primarily affects the respiratory system but can involve multiple organs.
- The extent and clinical impact of cardiovascular and multisystemic involvement in COVID-19 are not well understood.
Purpose of the Study:
- To investigate the prevalence and clinical significance of cardiovascular and multisystemic involvement in patients hospitalized with COVID-19.
- To assess myocardial injury and inflammation during the convalescent phase.
- To inform therapeutic and management strategies for COVID-19 patients.
Main Methods:
- Prospective, observational, multicentre, longitudinal cohort study.
- Enrollment of patients within 28 days of hospital discharge for COVID-19.
- Multisystem, multimodality imaging (cardiac MRI, CT coronary angiography) at 28 days post-discharge.
- Diagnosis of myocardial injury based on peak troponin I levels.
Main Results:
- Primary outcome: proportion of patients with myocardial inflammation.
- Assessment of heart, lung, and kidney involvement using advanced imaging techniques.
- Evaluation of longer-term health and well-being.
Conclusions:
- The CISCO-19 study will offer insights into the cardiovascular and multisystemic impact of COVID-19.
- Findings will guide the development of new treatments and management approaches for affected individuals.
Background:
COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear.
Methods:
This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation.
Conclusion:
CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients.
Clinical Trial Registration:
ClinicalTrials.gov identifier NCT04403607.
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