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It Takes Two to Tango: DPRs in ALS and SCA36
Niran Maharjan1, Smita Saxena1
1Department of Neurology, Inselspital University Hospital, 3010 Bern, Switzerland; Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland.
Neuron
|July 24, 2020
Abstract:
Dipeptide repeat proteins (DPRs) occur via repeat-associated non-AUG (RAN) translation. In this issue of Neuron, McEachin et al. (2020) show that the aggregation-prone poly(GA)-rich chimeric DPRs determine divergent poly(GP) mediated pathology between C9ALS/FTD and SCA36.

