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Multisystem inflammatory syndrome in children: Is there a linkage to Kawasaki disease?

Yue-Hin Loke1, Charles I Berul1, Ashraf S Harahsheh1

  • 1Department of Pediatrics, George Washington University School of Medicine & Health Sciences; 2300 I St NW, Washington, DC 20052; Division of Cardiology, Children's National Hospital; 111 Michigan Ave, NW Washington, DC 20010, USA.

Trends in Cardiovascular Medicine
|July 24, 2020
PubMed

Insights

Researchers are investigating the cause of Kawasaki Disease (KD), a condition since 1967. The COVID-19 pandemic

Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Epidemiology

Background:

  • Kawasaki Disease (KD) etiology remains elusive since 1967.
  • The COVID-19 pandemic introduced multisystem inflammatory syndrome in children (MIS-C).
  • MIS-C shares clinical similarities with KD, prompting etiological investigations.

Purpose of the Study:

  • To review current understanding of KD etiology.
  • To explore the potential link between KD and SARS-CoV-2 infection.
  • To compare KD with MIS-C in pediatric populations.

Main Methods:

  • Literature review of KD and MIS-C studies.
  • Comparative analysis of clinical and epidemiological features.
  • Discussion of potential infectious or environmental triggers.

Main Results:

  • No definitive etiology for KD has been established.
  • MIS-C emerged during the COVID-19 pandemic, affecting children.
  • Shared inflammatory pathways may exist between KD and MIS-C.

Conclusions:

  • Investigating MIS-C may offer insights into KD pathogenesis.
  • Further research is needed to confirm shared etiological factors.
  • Understanding these pediatric inflammatory syndromes is crucial.

Keywords:
COVID-19Kawasaki diseaseMultisystem inflammatory syndrome in children (MIS-C)Pediatric cardiologyPediatric multisystem inflammatory syndrome (PMIS)

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