SiPM signal readout for inter-crystal scatter event identification in PET detectors

In positron emission tomography (PET) with pixelated detectors, a significant number of annihilation photons interact with scintillation crystals through single or multiple Compton scattering events. When these partial energy depositions occur across multiple crystal elements, we call them inter-crystal scatter (ICS) events. ICS events lead to incorrect localization of the annihilation photons, thereby degrading the PET image contrast, spatial resolution, and lesion detectability. The accurate identification of ICS events is the first essential step to improve the quality of PET images by rejecting ICS events or recovering ICS events without losing PET sensitivity. In this study, we propose a novel silicon photomultiplier (SiPM) readout method to identify ICS events in one-to-one coupled PET detectors with a reduced number of data acquisition channels. For concept verification, we assembled a PET detector that consists of a 16-channel SiPM array and 4 [Formula: see text] 4 lutetium oxyorthosilicate (LSO) array with a 3.2 mm crystal pitch. The proposed SiPM readout scheme serializes the 16 SiPM anode signals into four pulse train outputs encoded with four increasing time-delays in steps of 250 ns intervals. A Sum signal of the 16 SiPM anodes provides the timing information for time-of-flight measurement and a trigger signal for coincidence detection. A time-over-threshold (TOT) method was applied for obtaining the energy information followed by a subsequent TOT-to-energy calibration. We successfully identified the ICS events and determined their interacted positions and deposited energies by analyzing the digital pulses from the four pulse train output channels. The occurrence rate of ICS events was 10.85% for the 4 × 4 PET detector module with 3.2 mm-pitch LSO crystals. The PET detector yielded an energy resolution of 10.9 [Formula: see text] 0.6% and coincidence timing resolution of 285 [Formula: see text] 12 ps FWHM. We expect that the proposed method can be a useful solution for alleviating the readout burden of SiPM-based PET scanners with ICS event identification capability.