A potential role for AHR in SARS-CoV-2 pathology

Area of Science:

• Virology
• Immunology
• Respiratory Medicine

Background:

• Coronavirus infections can lead to severe respiratory failure.
• The aryl hydrocarbon receptor (AHR) is a known host factor for Zika and dengue viruses.
• AHR antagonists have demonstrated efficacy in reducing viral loads and pathology for other viral infections.

Approach:

• Investigated the role of AHR activation in coronavirus infection.
• Assessed the impact of AHR on anti-viral immunity and lung basal cells.
• Evaluated AHR antagonists as potential therapeutic agents.

Key Points:

• Aryl hydrocarbon receptor (AHR) is activated during coronavirus infection.
• AHR activation negatively impacts anti-viral immunity.
• AHR influences lung basal cells crucial for tissue repair.

Conclusions:

• AHR plays a significant role in the pathogenesis of coronavirus infections.
• AHR antagonists represent a potential therapeutic strategy for managing coronavirus disease.
• Targeting AHR could mitigate respiratory complications associated with coronavirus infections.