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Updated: Dec 14, 2025

Microscopic Replantation of Penile Glans Amputation Due to Circumcision
Published on: June 3, 2022
Acute glans ischemia after circumcision successfully treated with low-molecular-weight heparin and topical
Zlatan Zvizdic1, Dusko Anic2, Nusret Popovic1
1Clinic of Pediatric Surgery.
Rationale:
Circumcision like any other surgical procedure is not devoid of complications. Serious complications are rare and include iatrogenic hypospadias, glans ischemia/necrosis, and glans amputation, all of which require an emergent treatment.
Patient Concerns:
We report here a case of 6 months-old-boy with a superficial glans ischemia following circumcision.
Diagnosis:
Physical examination revealed a severely cyanotic glans with the moderate edema of the dorsal penile skin. Plasma levels of D-dimer were 8.57 mg/L. Urine passage was unremarkable while color Doppler ultrasonography revealed a normal blood flow.
Interventions:
The patient was successfully treated with subcutaneous injection of enoxaparin (low-molecular-weight heparin) and topical 2.5% dihydrotestosterone.
Outcomes:
The appearance of the glans penis on the 5th day was close to normal while the control levels of D-dimer dropped to the reference range. The patient was discharged from the hospital on the 6th day. At 6-month follow-up, the appearance of the glans penis was normal.
Lessons:
Acute glans penis ischemia following circumcision is a rare complication. Its successful treatment with enoxaparin and topical dihydrotestosterone has not been previously reported in the literature.
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