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Extracorporeal Therapy in Sepsis
Deepak Govil1, G Praveen Kumar1
1Institute of Critical Care and Anesthesiology, Medanta - The Medicity, Gurugram, Haryana, India.
Insights
Extracorporeal therapy, including techniques like continuous renal replacement therapy, can be a vital supportive treatment for patients with severe sepsis. This approach aids in managing organ dysfunction and improving outcomes in critical care settings.
Area of Science:
- Critical care medicine
- Nephrology
- Intensive care
Background:
- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Severe sepsis and septic shock are associated with high mortality rates.
- Conventional treatments for sepsis may not be sufficient in managing severe cases and associated organ failures.
Purpose of the Study:
- To review the role and efficacy of extracorporeal therapies in the management of sepsis.
- To discuss various extracorporeal techniques applicable to sepsis patients.
- To highlight the potential benefits of these therapies in improving patient outcomes.
Main Methods:
- Review of existing literature on extracorporeal therapy in sepsis.
- Discussion of different extracorporeal modalities such as continuous renal replacement therapy (CRRT) and others.
- Analysis of their application in supporting failing organs during sepsis.
Main Results:
- Extracorporeal therapies can effectively support vital organ functions, particularly renal function, in septic patients.
- Techniques like CRRT can help in the removal of inflammatory mediators and fluid overload.
- Evidence suggests a potential benefit in reducing mortality and morbidity in select sepsis populations.
Conclusions:
- Extracorporeal therapy is a valuable adjunctive treatment for severe sepsis and septic shock.
- The judicious application of these therapies can aid in hemodynamic stabilization and organ support.
- Further research is warranted to optimize the use and timing of extracorporeal interventions in sepsis management.
Abstract:
How to cite this article: Govil D, Kumar GP. Extracorporeal Therapy in Sepsis. Indian J Crit Care Med 2020;24(Suppl 3):S117-S121.
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