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Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

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Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
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Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

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Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
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Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Continuous Renal Replacement Therapy01:30

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Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Updated: Dec 14, 2025

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
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Extracorporeal Therapy in Sepsis.

Deepak Govil1, G Praveen Kumar1

  • 1Institute of Critical Care and Anesthesiology, Medanta - The Medicity, Gurugram, Haryana, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|July 25, 2020
PubMed
Summary

Extracorporeal therapy, including techniques like continuous renal replacement therapy, can be a vital supportive treatment for patients with severe sepsis. This approach aids in managing organ dysfunction and improving outcomes in critical care settings.

Keywords:
CytokinesEndotoxinExtracorporeal therapySepsis

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Area of Science:

  • Critical care medicine
  • Nephrology
  • Intensive care

Background:

  • Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
  • Severe sepsis and septic shock are associated with high mortality rates.
  • Conventional treatments for sepsis may not be sufficient in managing severe cases and associated organ failures.

Purpose of the Study:

  • To review the role and efficacy of extracorporeal therapies in the management of sepsis.
  • To discuss various extracorporeal techniques applicable to sepsis patients.
  • To highlight the potential benefits of these therapies in improving patient outcomes.

Main Methods:

  • Review of existing literature on extracorporeal therapy in sepsis.
  • Discussion of different extracorporeal modalities such as continuous renal replacement therapy (CRRT) and others.
  • Analysis of their application in supporting failing organs during sepsis.

Main Results:

  • Extracorporeal therapies can effectively support vital organ functions, particularly renal function, in septic patients.
  • Techniques like CRRT can help in the removal of inflammatory mediators and fluid overload.
  • Evidence suggests a potential benefit in reducing mortality and morbidity in select sepsis populations.

Conclusions:

  • Extracorporeal therapy is a valuable adjunctive treatment for severe sepsis and septic shock.
  • The judicious application of these therapies can aid in hemodynamic stabilization and organ support.
  • Further research is warranted to optimize the use and timing of extracorporeal interventions in sepsis management.