Transition-metal-catalyzed C-H functionalization of pyrazoles
Eunsu Kang1, Hyun Tae Kim1, Jung Min Joo1
1Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Republic of Korea. jmjoo@pusan.ac.kr.
Abstract:
This review describes recent advances in transition-metal-catalyzed C-H functionalization reactions of pyrazoles to form new C-C and C-heteroatom bonds on the pyrazole ring. In contrast to traditional cross-coupling reactions that require pre-functionalized pyrazoles, direct C-H functionalization reactions provide access to a wide range of functionalized pyrazoles in a single step. Various strategies are presented and the efficiency and regioselectivity are described with respect to the types of functional groups that are installed.
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