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Trichosporonosis Presenting as an Exophytic Cutaneous Mass Lesion

Jorge Salazar1, Kaitlyn A Hardin2, Nathan P Wiederhold3

  • 1Department of Internal Medicine, University of California-Davis Health, Sacramento, CA, USA.

Mycopathologia
|July 25, 2020
PubMed

Insights

Rare yeasts like Trichosporon asahii are causing serious infections in immunocompromised patients. This case highlights a new toe lesion presentation of disseminated trichosporonosis, emphasizing early diagnosis and aggressive treatment for breakthrough fungal infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases

Background:

  • Opportunistic fungal infections are rising due to increased immunocompromised populations.
  • Emerging pathogens, including rare yeasts, cause significant morbidity and mortality.
  • Antifungal prophylaxis is often insufficient against breakthrough infections.

Observation:

  • A patient with acute myeloid leukemia developed an exophytic toe lesion.
  • The lesion was diagnosed as disseminated trichosporonosis.
  • The causative agent was identified as Trichosporon asahii.

Findings:

  • This case presents a previously unreported manifestation of disseminated trichosporonosis.
  • Trichosporon asahii can present as an exophytic lesion on the toe.
  • Breakthrough fungal infections require a high index of suspicion for diagnosis.

Implications:

  • Highlights the need for vigilance in diagnosing rare fungal infections.
  • Underscores the importance of aggressive treatment strategies for disseminated trichosporonosis.
  • Informs clinical practice regarding emerging opportunistic fungal pathogens in vulnerable populations.
Keywords:
Rare yeastsTrichosporonVoriconazole

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