Benzothiazoles as potential antiviral agents
Yahya I Asiri1, Abdulrhman Alsayari2, Abdullatif B Muhsinah2
1Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
The Journal of Pharmacy and Pharmacology
|July 25, 2020
Summary
The development of benzothiazole-based antiviral agents is crucial for combating emerging viral diseases. This review highlights 64 novel lead molecules and their structure-activity relationships, aiding future drug design.
Area of Science:
- Medicinal Chemistry
- Virology
- Drug Discovery
Background:
- The recent viral pandemic underscores the inadequacy of current antiviral pipelines against evolving viral threats.
- There is an urgent need for novel vaccines, diagnostics, and therapeutic agents to address viral pandemics.
Purpose of the Study:
- To review recent advancements in benzothiazole-based antiviral agents.
- To focus on structure-activity relationships and lead optimization of these compounds.
- To provide insights for designing future broad-spectrum antiviral agents.
Main Methods:
- Systematic literature search identifying 105 relevant articles.
- Analysis of identified articles to extract key findings and novel lead molecules.
- Focus on structure-activity relationships and lead optimization strategies.
Main Results:
- Identified 64 potential novel benzothiazole-based antiviral lead molecules.
- Highlighted key findings related to their antiviral activity and development.
- Emphasized the role of benzothiazole scaffold in antiviral drug design.
Conclusions:
- Benzothiazole derivatives are pivotal in developing effective antiviral drugs.
- This review offers a perspective on improving the design of novel, broad-spectrum benzothiazole-based antiviral agents.
- Future research should focus on optimizing these agents for emerging viral diseases.
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