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Preliminary reports on hyperbaric oxygen therapy in multiple sclerosis
K Ulewicz1, R Dolmierski, J Masłowski
1Institute of Maritime and Tropical Medicine, Gdynia.
Bulletin of the Institute of Maritime and Tropical Medicine in Gdynia
|January 1, 1988
Summary
Hyperbaric oxygen therapy showed significant improvements in most multiple sclerosis patients. This treatment reduced immunoglobulin levels and increased complement activity, offering a potential new avenue for managing MS symptoms.
Area of Science:
- Neurology
- Immunology
- Hyperbaric Medicine
Background:
- Multiple sclerosis (MS) is a chronic neurological disease affecting the central nervous system.
- Current treatments for MS aim to manage symptoms and slow disease progression, but novel therapeutic approaches are needed.
Purpose of the Study:
- To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) in patients with multiple sclerosis.
- To assess the impact of HBOT on clinical symptoms and immunological parameters in MS patients.
Main Methods:
- 16 patients with multiple sclerosis underwent 25-30 HBOT sessions at 2 atmospheres absolute (ata) oxygen pressure.
- Clinical status was assessed using the Kurtzke Disability Status Scale.
- Immunological markers including immunoglobulin (IgG, IgM, IgA) levels, complement activity, and T and B lymphocyte counts were quantified.
Main Results:
- 14 out of 16 patients experienced significant clinical improvement.
- One patient showed worsening of symptoms after 15 exposures, leading to treatment cessation.
- Immunological findings included a decrease in serum IgG, IgM, and IgA, and an increase in complement activity, while T and B lymphocyte counts remained unchanged.
Conclusions:
- Hyperbaric oxygen therapy demonstrates a promising therapeutic effect in a majority of multiple sclerosis patients.
- HBOT may modulate immune responses, evidenced by changes in immunoglobulin and complement levels.
- Further research is warranted to elucidate the mechanisms and long-term effects of HBOT in multiple sclerosis management.
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