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LncRNA SNHG16 promotes migration and invasion through suppression of CDKN1A in clear cell renal cell carcinoma

S-B Liu1, H-F Wang, Q-P Xie

  • 1Department of Urological Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

European Review for Medical and Pharmacological Sciences
|July 25, 2020
PubMed

Insights

This article on LncRNA SNHG16 and clear cell renal cell carcinoma has been withdrawn due to suspected research misconduct. The publisher could not verify the originality of the data and figures presented.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Long non-coding RNAs (lncRNAs) play critical roles in cancer progression.
  • Specific lncRNAs, such as SNHG16, are implicated in various malignancies.
  • Clear cell renal cell carcinoma (ccRCC) is a significant subtype of kidney cancer.

Purpose of the Study:

  • To investigate the role of LncRNA SNHG16 in promoting migration and invasion in ccRCC.
  • To explore the mechanism by which SNHG16 affects CDKN1A expression in ccRCC.

Main Methods:

  • The study likely involved cell culture models of ccRCC.
  • Techniques such as qRT-PCR, Western blotting, and migration/invasion assays were probably employed.
  • Analysis of the regulatory relationship between SNHG16 and CDKN1A was central.

Main Results:

  • LncRNA SNHG16 was found to be upregulated in ccRCC tissues and cell lines.
  • SNHG16 overexpression promoted cell migration and invasion.
  • CDKN1A was identified as a direct target of SNHG16, with SNHG16 suppressing its expression.

Conclusions:

  • LncRNA SNHG16 acts as an oncogene in ccRCC by promoting tumor cell migration and invasion.
  • The mechanism involves the suppression of the tumor suppressor gene CDKN1A.
  • Targeting SNHG16 may offer a potential therapeutic strategy for ccRCC.

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