Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.6K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.6K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

1.6K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
1.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.1K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.1K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.9K
Breathing01:05

Breathing

63.8K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
63.8K
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

892
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
892

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Navigating the path: Advice to physician-scientists on choosing a clinical specialty.

eLife·2026
Same author

Diazepam Relaxes Murine Peripheral Airway Smooth Muscle Through Inhibition of Phosphodiesterase 4 and Intracellular Calcium Oscillations.

American journal of respiratory cell and molecular biology·2026
Same author

Exposure to electronic cigarette aerosols triggers alterations in genomic DNA methylation that impacts cancer pathways in mice.

Inhalation toxicology·2026
Same author

Increased <i>S. epidermidis</i> in the airway-gut microbiome of infants with bronchopulmonary dysplasia.

bioRxiv : the preprint server for biology·2026
Same author

Sphingosine-1-phosphate - sphinganine-1-phosphate Imbalance Drives Airway Hyperreactivity.

medRxiv : the preprint server for health sciences·2026
Same author

Development of novel pegylated imidazobenzodiazepines as inhaled asthma drug candidates.

Respiratory medicine·2025

Related Experiment Video

Updated: Dec 13, 2025

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

23.1K

Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity.

Andrea F Heras1, Arul Veerappan2, Randi B Silver2

  • 1Department of Pediatrics.

American Journal of Respiratory Cell and Molecular Biology
|July 25, 2020
PubMed
Summary

Targeting sphingolipid synthesis may treat asthma. GlyH-101 and fenretinide modulated sphingolipid metabolites, reduced airway smooth muscle contraction, and decreased airway hyperreactivity (AHR) in mice.

Keywords:
asthmade novo synthesissmooth musclesphingolipid

More Related Videos

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

3.8K
Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
07:36

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

1.8K

Related Experiment Videos

Last Updated: Dec 13, 2025

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

23.1K
A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

3.8K
Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
07:36

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

1.8K

Area of Science:

  • Biochemistry
  • Pulmonology
  • Metabolic Therapeutics

Background:

  • Impaired sphingolipid synthesis is genetically linked to childhood asthma.
  • Sphingolipid metabolism dysfunction is functionally associated with airway hyperreactivity (AHR).

Purpose of the Study:

  • To investigate sphingolipid synthesis as a potential therapeutic target for asthma.
  • To evaluate the effects of GlyH-101 and fenretinide on AHR by modulating de novo sphingolipid synthesis.

Main Methods:

  • Assessed the impact of GlyH-101 and fenretinide on de novo sphingolipid synthesis in SPT-deficient mice.
  • Examined drug effects on sphingolipid metabolites, intracellular calcium concentration, and airway smooth muscle contraction in human cells.
  • Evaluated AHR in vivo in SPT-deficient mice treated with GlyH-101.

Main Results:

  • GlyH-101 and fenretinide increased de novo sphingolipid metabolites (sphinganine, dihydroceramides) in lung and airway smooth muscle cells.
  • These drugs reduced intracellular calcium concentration and agonist-induced contraction in airway smooth muscle.
  • GlyH-101 demonstrated a reduction in AHR in SPT-deficient mice.

Conclusions:

  • Modulating sphingolipid synthesis is a novel metabolic strategy for alleviating AHR.
  • Targeting de novo sphingolipid synthesis pathways shows promise for asthma therapeutics.