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Updated: Dec 13, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
MAM domain containing 2 is a potential breast cancer biomarker that exhibits tumour-suppressive activity
Hyeonhee Lee1, Bum-Chan Park2, Jong Soon Kang3
1Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon, Republic of Korea.
Objectives:
The aim of this study was to discover new potential biomarkers of breast cancer and investigate their cellular functions.
Materials And Methods:
We analysed the gene expression profiles of matched pairs of breast tumour and normal tissues from 24 breast cancer patients. Tetracycline-inducible MAMDC2 expression system was established and used to evaluate cell proliferation in vitro and in vivo. MAMDC2-mediated signalling was determined using immunoblot analysis.
Results:
We identified MAMDC2 as a down-regulated gene showing significant prognostic capability. Overexpression of MAMDC2 or treatment with MAMDC2-containing culture medium significantly inhibited the cell proliferation of T-47D cells. Furthermore, MAMDC2 expression reduced in vivo growth of T-47D xenograft tumours. MAMDC2 may exert its growth-inhibitory functions by attenuating the MAPK signalling pathway.
Conclusion:
We report that MAMDC2 has a tumour-suppressive role and, as a secretory protein, it might be useful as a biomarker for breast cancer treatment.
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