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Targeting STAT3 and STAT5 in Cancer

Elvin D de Araujo1,2, György M Keserű3, Patrick T Gunning1,2

  • 1Centre for Medicinal Chemistry, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.

Cancers
|July 26, 2020
PubMed

Insights

Advances in cancer biology have doubled the number of identified human cancer driver genes from 140 in 2013 to 300 in 2018. This highlights progress in understanding the cancer genome.

Area of Science:

  • Genomics
  • Cancer Biology
  • Bioinformatics

Background:

  • The human cancer genome's mutational landscape is crucial for understanding cancer development.
  • Early studies identified approximately 140 distinct cancer driver genes.

Discussion:

  • Significant advancements in systems cancer biology have propelled research.
  • The number of known cancer driver genes has approximately doubled.

Key Insights:

  • By 2018, around 300 distinct cancer driver genes were identified.
  • This expansion reflects improved analytical techniques and broader data integration.

Outlook:

  • Future research will likely uncover more driver genes, refining cancer classification.
  • Understanding these genes is vital for developing targeted cancer therapies.

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