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The Roles of Immune Cells in the Pathogenesis of Fibrosis

Enyu Huang1, Na Peng2, Fan Xiao1

  • 1Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China.

International Journal of Molecular Sciences
|July 26, 2020
PubMed

Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.

Keywords:
adaptive immune cellsfibrosisinnate immune cellsmolecular mechanismmyofibroblast

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