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Updated: Dec 13, 2025

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
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Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

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The Diverse Roles of Monocytes in Cryptococcosis

Man Shun Fu1, Rebecca A Drummond1

  • 1Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham B15 2TT, UK.

Journal of Fungi (Basel, Switzerland)
|July 26, 2020
PubMed

Insights

Monocytes are crucial in Cryptococcus neoformans infection, acting as both defenders and contributors to disease progression. This review explores their complex roles and how the fungus impacts these vital immune cells.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Mycology

Background:

  • Monocytes are central to Cryptococcus neoformans infection pathogenesis.
  • They can control infection but also promote fungal spread and detrimental responses.
  • The fungal capsule impairs monocyte function, complicating host defense.

Purpose of the Study:

  • To review monocyte-specific functions in cryptococcal infection.
  • To examine the impact of C. neoformans on monocyte responses.
  • To discuss monocyte heterogeneity and technological advancements.

Main Methods:

  • Literature review of immunological and mycological studies.
  • Analysis of host-pathogen interactions.
  • Discussion of emerging technologies for monocyte research.

Main Results:

  • Monocytes exhibit dual roles in cryptococcal infection.
  • C. neoformans actively modulates monocyte functions.
  • Monocyte heterogeneity influences infection outcomes.

Conclusions:

  • Monocytes are complex immune effectors, not just precursors, in cryptococcosis.
  • Understanding monocyte heterogeneity is key to developing new therapies.
  • Advanced technologies offer new avenues to study these interactions.
Keywords:
Cryptococcus neoformansflow cytometryinflammatory monocytesmass cytometrymonocyte subsetsmonocytessingle-cell RNA-seqtrained immunity

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