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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Updated: Dec 13, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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DNA Methylation Dysfunction in Chronic Kidney Disease.

Diego Ingrosso1, Alessandra F Perna2

  • 1Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Genes
|July 26, 2020
PubMed
Summary
This summary is machine-generated.

Epigenetic alterations, specifically DNA methylation, are increasingly implicated in the progression of renal disease. Understanding these changes offers potential for improved treatments and outcomes in kidney patients.

Keywords:
CKDDNA methylationESRDdialysisdisease markersepigenetic regulationmethylation reactionsrenal failure

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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
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Area of Science:

  • Nephrology
  • Epigenetics
  • Molecular Biology

Background:

  • Renal disease prevalence is rising globally.
  • Chronic kidney disease (CKD) requires long-term management.
  • Cardiovascular disease is a major cause of mortality in CKD patients.

Purpose of the Study:

  • To review the role of DNA methylation in renal disease.
  • To explore the potential of epigenetic modifications in managing kidney disease.

Main Methods:

  • Literature review focusing on DNA methylation and renal disease.
  • Analysis of current evidence on epigenetic derangements in kidney conditions.

Main Results:

  • Evidence suggests derangements in epigenetic control of gene expression in renal disease.
  • DNA methylation patterns are altered in various kidney diseases.

Conclusions:

  • Epigenetic modifications, particularly DNA methylation, are crucial in renal disease pathogenesis.
  • Targeting epigenetic pathways may offer novel therapeutic strategies for kidney disease.
  • Further research into DNA methylation can improve disease progression prediction and management.