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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
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Narrow-Margin Excision for Invasive Acral Melanoma: Is It Acceptable?

Takamichi Ito1, Yumiko Kaku-Ito1, Maiko Wada-Ohno1

  • 1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Journal of Clinical Medicine
|July 26, 2020
PubMed
Summary
This summary is machine-generated.

Narrow-margin excision for acral melanoma showed similar outcomes to standard margins for early stages. However, advanced T4 melanoma patients had higher mortality with narrow margins, suggesting adherence to guidelines is crucial.

Keywords:
acral lentiginous melanomaprognosissurgery

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Area of Science:

  • Dermatology
  • Surgical Oncology

Background:

  • Acral melanoma is an infrequent but aggressive skin cancer.
  • Optimal surgical margins for acral melanoma remain debated.

Purpose of the Study:

  • To evaluate the safety and efficacy of narrow-margin excision versus National Comprehensive Cancer Network (NCCN)-recommended margins for primary invasive acral melanoma.

Main Methods:

  • Retrospective review of 100 patients with acral melanoma.
  • Comparison of outcomes between narrow-margin (N-group) and NCCN-recommended margin (R-group) excision.
  • Analysis of margin status, recurrence, mortality, and survival rates.

Main Results:

  • Local recurrence and positive margins were rare for both groups.
  • Similar mortality rates for T1-3 melanomas in both groups.
  • Higher mortality observed in T4 melanoma patients treated with narrow margins compared to R-group.
  • Breslow thickness, not surgical margin, was an independent risk factor for survival.

Conclusions:

  • Narrow-margin excision may be safe for early-stage acral melanoma but poses higher risks for T4 tumors.
  • Current NCCN guidelines for surgical margins should be followed.
  • Prospective data collection is needed to better define acral melanoma prognosis.