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Earlier Nutrient Fortification of Breastmilk Fed LBW Infants Improves Jaundice Related Outcomes

Xiao Wei Ma1, Wei Qi Fan1,2

  • 1Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Grattan Street, Melbourne, VIC 3010, Australia.

Nutrients
|July 26, 2020
PubMed

Insights

Earlier nutrient supplementation for premature infants significantly improved jaundice outcomes and reduced feeding intolerance. This approach also led to shorter hospital stays and faster birth weight regain, with no adverse effects.

Area of Science:

  • Neonatalogy
  • Pediatric Gastroenterology
  • Clinical Nutrition

Background:

  • Jaundice is a common condition in low-birthweight premature infants.
  • Nutrient supplementation timing is a critical factor in neonatal care.
  • Previous research has not fully elucidated the impact of early versus late nutrient administration on jaundice and related outcomes.

Purpose of the Study:

  • To evaluate the effect of earlier versus later nutrient supplementation on jaundice outcomes in low-birthweight premature infants.
  • To compare clinical outcomes, including feeding intolerance and length of stay, between the two supplementation groups.

Main Methods:

  • A comparative study involving low-birthweight premature infants receiving either early (80 mL/kg/day) or late (160 mL/kg/day) nutrient supplementation.
  • Collection of data on demographics, feeding regimens, and clinical outcomes, including serum bilirubin levels and phototherapy use.
  • Statistical analysis to compare jaundice parameters, feeding intolerance, length of stay, and weight changes between groups.

Main Results:

  • Earlier nutrient supplementation (F80) was associated with significantly lower total serum bilirubin (TSBR) and conjugated serum bilirubin (CSBR) values.
  • F80 group showed reduced need for phototherapy (39% vs. 64%), decreased feeding intolerance (26.0% vs. 45.2%), and shorter length of stay (16.0 vs. 18.8 days).
  • F80 infants experienced less maximum weight loss, improved weight Z-score at 10 days, and earlier regain of birthweight compared to the F160 group.

Conclusions:

  • Earlier nutrient supplementation in low-birthweight premature infants positively impacts jaundice outcomes, potentially through enhanced bilirubin excretion.
  • Early supplementation also confers benefits such as reduced feeding intolerance, shorter hospital stays, and improved weight gain dynamics.
  • These findings suggest that optimizing the timing of nutrient supplementation is a valuable strategy in managing premature neonates.

Keywords:
LBWfortificationhyperbilirubinemiajaundicepreterm

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