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Impact of Galectins in Resistance to Anticancer Therapies

Pilar Navarro1,2,3, Neus Martínez-Bosch2, Ada G Blidner4

  • 1Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain. gabyrabi@gmail.com pilar.navarro@iibb.csic.es.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|July 26, 2020
PubMed

Insights

Galectins, a family of proteins, play key roles in cancer progression and response to therapies. Targeting galectins may enhance the effectiveness of cancer treatments by overcoming resistance.

Area of Science:

  • Biochemistry
  • Oncology
  • Immunology

Background:

  • Galectins are endogenous β-galactoside-binding proteins involved in numerous cellular processes.
  • These proteins significantly influence cancer progression, affecting proliferation, migration, angiogenesis, and immune evasion.

Purpose of the Study:

  • To explore the diverse functions of galectins in cancer.
  • To elucidate the role of galectins in mediating sensitivity or resistance to anticancer therapies.

Main Methods:

  • Literature review and integrated analysis of galectin functions.
  • Discussion of galectin involvement in various anticancer treatment modalities.

Main Results:

  • Galectins modulate key cancer hallmarks like proliferation, invasion, and immune escape.
  • Galectins are identified as critical determinants of response to chemotherapy, radiotherapy, targeted therapy, antiangiogenesis, and immunotherapy.

Conclusions:

  • Galectins exhibit pleiotropic functions throughout cancer progression.
  • Targeting galectins or their ligands presents a promising strategy to overcome therapeutic resistance and improve anticancer efficacy.

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