Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

215
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
215
Heart Valves01:16

Heart Valves

10.3K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
10.3K
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

300
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
300
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

231
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
231

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An optimal Petrov-Galerkin framework for operator networks.

Computer methods in applied mechanics and engineering·2026
Same author

A computational approach that accounts for hydrogel compressibility in cellular traction force microscopy.

Computers in biology and medicine·2026
Same author

Reconstruction of glymphatic transport fields from subject-specific imaging data, with particular emphasis on cerebrospinal fluid flow and tracer conservation.

ArXiv·2026
Same author

Image-based high-throughput phenotyping enables genetic analyses of pod morphological traits in mungbean (Vigna radiata (L.) R. Wilczek).

G3 (Bethesda, Md.)·2026
Same author

MaizeField3D: A curated 3D point cloud and procedural model dataset of field-grown maize from a diversity panel.

Plant phenomics (Washington, D.C.)·2026
Same author

Biomechanical index for predicting the risk of acute coronary syndrome.

Frontiers in cardiovascular medicine·2026

Related Experiment Video

Updated: Dec 13, 2025

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets
10:29

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

Published on: March 23, 2022

4.7K

Thinner biological tissues induce leaflet flutter in aortic heart valve replacements.

Emily L Johnson1, Michael C H Wu1, Fei Xu1

  • 1Department of Mechanical Engineering, Iowa State University, Ames, IA 50011.

Proceedings of the National Academy of Sciences of the United States of America
|July 26, 2020
PubMed
Summary

New research reveals that thinner bioprosthetic valve tissues, used in minimally invasive heart valve replacement, can cause dangerous leaflet flutter. This finding highlights potential risks like blood damage and accelerated tissue wear, impacting cardiac system understanding and device innovation.

Keywords:
fluid–structure interactionheart valvesimmersogeometric analysisleaflet flutterthin biological tissues

More Related Videos

Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification
07:34

Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification

Published on: February 10, 2022

2.3K
Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
11:00

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

14.7K

Related Experiment Videos

Last Updated: Dec 13, 2025

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets
10:29

Combining 3D-Printing and Electrospinning to Manufacture Biomimetic Heart Valve Leaflets

Published on: March 23, 2022

4.7K
Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification
07:34

Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification

Published on: February 10, 2022

2.3K
Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
11:00

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

14.7K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Computational Fluid Dynamics

Background:

  • Valvular heart disease is a growing public health issue, particularly in aging populations.
  • Catheter-based bioprosthetic valve replacement is a less invasive alternative to surgery for severe aortic valve disease.
  • Advancements in percutaneous devices include thinner, more flexible biological tissues, but their in-vivo behavior is not well understood.

Purpose of the Study:

  • To investigate the biomechanical behavior of thinner, more compliant aortic valve tissues within a physiological system.
  • To identify and quantify potential adverse effects of these advanced materials in the dynamic cardiac environment.

Main Methods:

  • Utilized a validated computational fluid-structure interaction (FSI) approach.
  • Simulated thinner aortic valve tissues in a physiologically realistic computational model.
  • Analyzed fluid dynamics and leaflet motion under simulated cardiac conditions.

Main Results:

  • Identified and quantified significant leaflet flutter with the use of thinner valve tissues.
  • Observed initiation of blood flow disturbances and oscillatory leaflet strains due to flutter.
  • Documented previously unidentified aortic flow and valvular dynamics associated with these thinner tissues.

Conclusions:

  • Thinner, more flexible aortic valve tissues can induce potentially harmful leaflet flutter.
  • Flutter phenomena pose risks including blood damage and accelerated leaflet deterioration.
  • Findings advance fundamental knowledge of cardiac dynamics and inform future medical device design for valve replacement.