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Role of hyperhomocysteine, thyroid dysfunction and their interaction in ischemic stroke patients with non-valvular

Lili Wang1, Yun Zhang2

  • 1Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. bitljq2012@163.com.

Scientific Reports
|July 26, 2020
PubMed

Insights

Hyperhomocysteinemia and thyroid dysfunction are linked to atrial fibrillation in ischemic stroke patients, particularly in women. However, these two conditions do not appear to be related to each other in this patient group.

Area of Science:

  • Neurology
  • Endocrinology
  • Cardiology

Background:

  • Hyperhomocysteinemia (HHcy) and thyroid dysfunction are potential risk factors for ischemic stroke.
  • Their specific roles and interrelationships in patients with non-valvular atrial fibrillation (AF) remain unclear.
  • Investigating these factors is crucial for understanding stroke etiology in AF patients.

Purpose of the Study:

  • To examine the association of HHcy and thyroid dysfunction with ischemic stroke in patients with non-valvular AF.
  • To explore the relationship between HHcy and thyroid dysfunction within this specific patient cohort.
  • To identify potential risk factors contributing to stroke in AF patients.

Main Methods:

  • A cohort of 717 patients with acute ischemic stroke within 7 days of symptom onset was analyzed.
  • Patients were categorized into groups with and without AF.
  • Serum homocysteine (Hcy) and thyroid-stimulating hormone levels were measured; multivariable logistic regression and Spearman correlation were employed.

Main Results:

  • Of 717 patients, 122 had AF. HHcy was present in 40.2% and thyroid dysfunction in 44.1%.
  • Significant differences in serum Hcy and thyroxine levels were observed between patients with and without AF, notably in female subgroups.
  • No significant association was found between HHcy and thyroid dysfunction in the AF group (P=0.463).

Conclusions:

  • Both HHcy and thyroid dysfunction are independently associated with AF in acute ischemic stroke patients, especially in females.
  • Thyroid dysfunction does not show a relationship with HHcy in ischemic stroke patients with AF.
  • Further research may elucidate the mechanisms linking these conditions to stroke in AF.

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