Understanding psychophysiological interaction and its relations to beta series correlation.
Xin Di1,2, Zhiguo Zhang3,4, Bharat B Biswal5,6
1School of Life Sciences and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Brain Imaging and Behavior
|July 26, 2020
Summary
Psychophysiological interaction (PPI) and beta series correlation (BSC) analyze task-modulated functional connectivity (FC) in fMRI. This study clarifies PPI interpretation and its relationship with BSC, showing they detect similar connectivity differences.
Area of Science:
- Neuroimaging
- Cognitive Neuroscience
- Data Analysis
Background:
- Psychophysiological interaction (PPI) is a 20-year-old method for analyzing task-modulated functional connectivity (FC) in functional MRI (fMRI).
- Misunderstandings persist regarding PPI's interpretation and its relationship with similar methods like beta series correlation (BSC).
Purpose of the Study:
- To clarify the precise measurement of PPI and its relationship with BSC.
- To address common misunderstandings about PPI in the context of general linear model (GLM) analysis.
- To illustrate how PPI and BSC detect similar connectivity differences, especially in the presence of context-sensitive changes.
Main Methods:
- Explanation of PPI regressor interpretation within the GLM framework, considering covariates.
- Description of how direct contrasts in multi-condition PPI models yield results similar to generalized PPI.
- Elucidation of the deconvolution process in PPI and its relation to trial-by-trial modeling used in BSC.
Main Results:
- PPI analysis, when including a physiological variable as a covariate, consistently reflects connectivity differences between conditions.
- Generalized PPI models produce identical results to contrasting separate PPIs for each condition.
- Empirical analysis on fMRI data from a stop-signal task demonstrates that both PPI and BSC can detect similar functional connectivity differences.
Conclusions:
- PPI measures differences in functional connectivity between experimental conditions.
- PPI and BSC are related methods capable of detecting context-sensitive changes in effective connectivity.
- A clear understanding of PPI and its relationship to BSC is crucial for accurate fMRI data interpretation.
Keywords:
Beta seriesDeconvolutionEvent-related designFunctional connectivityPsychophysiological interactionMore Related Videos
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