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The Relationship Between the Level of Serum ESM-1 and Lp-PLA2 in Patients With Acute ST-Segment Elevation Myocardial

Peng Wei1,2, Bin Zong2, Xuekui Liu3

  • 1Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.

Clinical and Translational Science
|July 26, 2020
PubMed

Insights

Endothelial cell-specific molecule 1 (ESM-1) and lipoprotein-associated phospholipase A2 (Lp-PLA2) are elevated in acute ST-segment elevation myocardial infarction (STEMI) patients. These biomarkers are significantly correlated, suggesting their potential as diagnostic tools for STEMI.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Inflammation Research

Background:

  • Acute ST-segment elevation myocardial infarction (STEMI) is a critical cardiovascular disease characterized by endothelial dysfunction and inflammation.
  • Endothelial cell-specific molecule 1 (ESM-1) and lipoprotein-associated phospholipase A2 (Lp-PLA2) are implicated in STEMI pathogenesis.
  • The correlation between ESM-1 and Lp-PLA2 in STEMI patients remains unexplored.

Purpose of the Study:

  • To investigate the serum levels of ESM-1 and Lp-PLA2 in patients with acute STEMI.
  • To evaluate the relationship and clinical significance of ESM-1 and Lp-PLA2 as potential biomarkers for acute STEMI.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum ESM-1 and Lp-PLA2 levels.
  • A cohort of 37 acute STEMI patients and 24 healthy controls was studied.
  • Blood samples were collected from the median cubital vein upon patient enrollment.

Main Results:

  • Serum levels of ESM-1 and Lp-PLA2 were significantly higher in STEMI patients compared to controls (P < 0.05).
  • A strong positive correlation was observed between serum ESM-1 and Lp-PLA2 levels (r² = 0.8131, P < 0.0001).

Conclusions:

  • ESM-1, an endothelial dysfunction marker, and Lp-PLA2, an inflammatory marker, are significantly elevated and correlated in acute STEMI.
  • These biomarkers demonstrate potential as novel and effective indicators for the diagnosis and evaluation of acute STEMI.

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