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Updated: Dec 13, 2025
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Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
Published on: August 11, 2016
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Identifying and characterizing basal cell carcinomas in persons with albinism
Margit L W Juhasz1, Melissa K Levin2,3,4, Andrew Sharp4,5
1Department of Dermatology, University of California, Irvine, Irvine, CA, USA.
International Journal of Dermatology
|July 26, 2020
Summary
Basal cell carcinoma (BCC) is more common than squamous cell carcinoma (SCC) in persons with albinism (PWA), contrary to historical beliefs. Early recognition of BCC in PWA is crucial to reduce disease burden and mortality.
Area of Science:
- Dermatology
- Oncology
- Genetics
Background:
- Historically, squamous cell carcinoma (SCC) was considered more frequent than basal cell carcinoma (BCC) in persons with albinism (PWA).
- Emerging evidence indicates a higher prevalence of BCC in PWA than previously hypothesized.
Purpose of the Study:
- To investigate and characterize the clinical presentation of basal cell carcinoma (BCC) in persons with albinism (PWA).
Main Methods:
- A study involving 54 PWA with suspected non-melanoma skin cancer lesions was conducted at Tanzanian dermatologic clinics between 2017 and 2019.
- Demographic and clinical data were collected, and all lesions underwent histologic analysis.
Main Results:
- Histologic analysis confirmed BCC in 30.2% of lesions, SCC in 26.4%, and Bowen's disease in 17%.
- The majority of PWA were female (53.7%), with a mean age of 34.6 years.
- Common lesion presentations included ulceration (41.7%) and locations on the trunk (47.1%) and face (41.2%).
Conclusions:
- Basal cell carcinoma (BCC) appears to occur at a higher rate than SCC in this PWA population, suggesting underdiagnosis of BCC.
- Prompt identification and management of BCC in PWA are essential to mitigate significant morbidity and mortality.
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