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Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway

Wen-Hong Dong1, Qiang-Qiang Chu1, Shang-Quan Liu2

  • 1Department of General Practice, The First people's Hospital of Hefei, Hefei, China.

Journal of Food Biochemistry
|July 26, 2020
PubMed

Insights

Isobavachalcone (ISO) shows promise in protecting kidneys from diabetic nephropathy (DN). This compound reduced key markers of kidney damage and inflammation in diabetic rats, suggesting potential as a dietary supplement for DN management.

Area of Science:

  • Pharmacology and Toxicology
  • Nephrology
  • Natural Product Chemistry

Background:

  • Diabetic nephropathy (DN) is a major complication of diabetes, leading to significant kidney damage.
  • Isobavachalcone (ISO), a compound found in Psoralea corylifolia L., possesses known anti-inflammatory properties.
  • The potential renoprotective effects of ISO against DN have not been extensively studied.

Purpose of the Study:

  • To evaluate the renoprotective effects of Isobavachalcone (ISO) in a rodent model of diabetic nephropathy (DN).
  • To investigate the underlying mechanisms of ISO's action, including its impact on inflammation and apoptosis.
  • To explore the potential of ISO as a dietary intervention for DN management.

Main Methods:

  • Diabetic nephropathy was induced in rats using a single injection of streptozotocin (STZ).
  • Diabetic rats were orally treated with ISO, and renal function markers (serum creatinine, BUN, urinary protein) were measured.
  • In vitro studies assessed ISO's effect on high glucose-induced human renal glomerular endothelial cells (HRGECs), including apoptosis and inflammatory mediator production.
  • The NF-κB pathway activation was examined in both in vivo and in vitro models.

Main Results:

  • ISO treatment significantly ameliorated renal damage in diabetic rats, evidenced by reduced BUN, serum creatinine, and 24-hour urinary protein levels.
  • Histopathological examination revealed improved kidney tissue appearance in ISO-treated rats.
  • ISO prevented STZ-induced apoptosis in glomerular tissue and inhibited high glucose-induced growth inhibition in HRGECs.
  • ISO suppressed pro-inflammatory mediator production and inhibited the NF-κB pathway in damaged renal tissues and HG-treated HRGECs.

Conclusions:

  • Isobavachalcone (ISO) demonstrates significant renoprotective effects against diabetic nephropathy (DN) in vivo and in vitro.
  • The protective action of ISO is associated with its anti-inflammatory effects, including the modulation of the NF-κB pathway.
  • ISO-enriched foods may offer a beneficial dietary strategy for individuals with diabetic nephropathy, potentially due to its anti-inflammatory and mild hypoglycemic properties.
Keywords:
diabetic nephropathyinflammationisobavachalconenuclear factor-κB

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