Related Experiment Video

Updated: Dec 13, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

Cardiac biomarkers of heart failure in chronic kidney disease

Xiaorong Han1, Shuai Zhang1, Zhongbo Chen1

  • 1Department of Cardiovascular Centre, The First Hospital of Jilin University, Changchun, Jilin 130021, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 26, 2020
PubMed

Insights

Heart failure biomarkers are challenging in chronic kidney disease (CKD) due to renal insufficiency. This review explores biomarker groups and suggests combining multiple biomarkers monitored over time for better clinical impact in CKD patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarker Research

Background:

  • Heart failure poses a significant risk to patients with chronic kidney disease (CKD).
  • Traditional heart failure biomarkers are often unreliable in CKD patients due to impaired renal function.
  • Accurate diagnosis and prognosis of heart failure in CKD require specialized biomarker approaches.

Purpose of the Study:

  • To review existing and emerging heart failure biomarkers applicable to CKD patients.
  • To discuss the challenges posed by renal insufficiency on biomarker interpretation.
  • To highlight the need for adjusted biomarker thresholds and combination strategies.

Main Methods:

  • Exploration of four major groups of heart failure biomarkers: myocardial stretch, myocyte injury, fibrosis/inflammation, and renal function.
  • Review of classic biomarkers with adjusted critical values for glomerular filtration rate (GFR).
  • Summary of recent research on novel biomarkers and future research directions.

Main Results:

  • Biomarkers for myocardial stretch (e.g., BNP, NT-proBNP), myocyte injury (e.g., hsTnT), fibrosis/inflammation (e.g., sST2, Gal-3), and renal function (e.g., NGAL, KIM-1) were analyzed.
  • Classic biomarkers require GFR-adjusted thresholds for reliable interpretation in CKD.
  • Emerging biomarkers show promise but require further validation.

Conclusions:

  • Interpreting heart failure biomarkers in CKD necessitates consideration of renal function.
  • Combining multiple biomarkers and monitoring them longitudinally offers greater clinical utility than single measurements.
  • Future research should focus on developing and validating novel biomarkers and combination strategies tailored for CKD populations.

Keywords:
BiomarkerChronic kidney diseaseGlomerular filtration rateHeart failure

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.6K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.3K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
412
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
659
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
427
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
198
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
436
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
246