Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T lymphocyte rosette formation after major burns.

B A Neilan, L Taddeini, R G Strate

    JAMA
    |August 8, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    16S rRNA gene amplicon sequencing data from an Australian wastewater treatment plant.

    Microbiology resource announcements·2024
    Same author

    Long-term stability of the genome structure of the cyanobacterium, Dolichospermum in a deep German lake.

    Harmful algae·2024
    Same author

    Microbiome analysis reveals <i>Microcystis</i> blooms endogenously seeded from benthos within wastewater maturation ponds.

    Applied and environmental microbiology·2023
    Same author

    Cyanobacteria as a critical reservoir of the environmental antimicrobial resistome.

    Environmental microbiology·2023
    Same author

    Hive Transplantation Has Minimal Impact on the Core Gut Microbiome of the Australian Stingless Bee, Tetragonula carbonaria.

    Microbial ecology·2023
    Same author

    Australian bush medicines harbour diverse microbial endophytes with broad-spectrum antibacterial activity.

    Journal of applied microbiology·2021

    Severe burns significantly reduce T lymphocyte numbers and function in patients. This study quantifies the decrease in T lymphocytes, indicating impaired cellular immunity post-burn.

    Area of Science:

    • Immunology
    • Burn Medicine
    • Cellular Biology

    Background:

    • Lymphocyte function is crucial for immune response.
    • Burn injuries can profoundly impact the immune system.
    • Quantifying T lymphocyte changes is vital for understanding post-burn immune deficits.

    Purpose of the Study:

    • To assess T lymphocyte levels in patients during the acute burn period.
    • To investigate the rosette-forming ability of lymphocytes as a marker for T lymphocytes.
    • To compare T lymphocyte counts in burn patients with healthy controls.

    Main Methods:

    • Studied 17 adult patients with burns >15% body surface area.
    • Serially monitored lymphocyte rosette-forming cell (RFC) counts post-burn.
    • Compared patient RFC counts to those of normal controls.

    Related Experiment Videos

    Main Results:

    • A significant decrease in absolute RFC numbers was observed 3-10 days post-burn (P < .001 and P < .01).
    • Percentage of total RFC was significantly lower in patients (48.9%) compared to controls (73.9%) (P < .01).
    • RFC reduction did not correlate with total lymphocyte count or cortisol levels.

    Conclusions:

    • T lymphocytes are decreased or exhibit altered rosette-forming ability in the early post-burn period.
    • Findings suggest impaired cellular immunity following severe burns.
    • The study highlights potential T lymphocyte dysfunction as a consequence of burn trauma.